Tag: tuberculosis

Laboratory diagnosis, treatment and prevention of Tuberculosis 4.43/5 (28)

Laboratory diagnosis, treatment and prevention of Tuberculosis

Laboratory diagnosis of Tuberculosis caused by Mycobacterium tuberculosis Specimen and processing sputum, bronchial washings, brushings or biopsies or early morning gastric aspirates, Cerebospinal Fluid (CSF), urine Specimens from sputum and other nonsterile sites should be liquefied with N-acetyl-L-cysteine decontaminated with NaOH (kills many other bacteria and fungi), neutralized with buffer, and concentrated by centrifugation. Specimens […]

Pathogenesis and Clinical manifestation of Mycobacterium tuberculosis 4.5/5 (20)

Pathogenesis and Clinical manifestation of Mycobacterium tuberculosis

Virulence factors of Mycobacterium tuberculosis A. Mycolic acid and Lipoarabinomannan (LAM) Waxy layer that protects the bacteria from many host factors and also to many antibiotics including beta lactamases. Muramyl dipeptide (from peptidoglycan) complexed with mycolic acids can cause granuloma formation, phospholipids induce caseous necrosis. LAM is structurally and functionally related to the O antigenic […]

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